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Colostrum Research(Bovine Colostrum):

Immunoglobulins:
Immunoglobulins have been shown to provide a superior defense in both treatment and prevention of viral infections, bacterial infections, allergies, fungus and yeast. There are five types of immunoglobulins present in colostrum, specifically IgA, IgD, IgE, IgG, & IgM. Bovine colostrum contains mostly IgG with very small amounts of IgA, IgD, IgE, and IgM. Human colostrum typically contains 2% IgG content, while bovine colostrum can have from 8% to above 25% IgG content. These are protein molecules that are effective in fighting bacterial and viral infections (colds, flu, etc.), parasites, and yeast. Immunoglobulins are energizing elements in colostrum that are anti-inflammatory in nature. High quality bovine colostrum contains a minimum of 20% immunoglobulins.

Antibodies:
Colostrum has been shown to contain specific antibodies to more than 19 specific disease-causing pathogens including; rotavirus, h. pylori, cryptosporidium, salmonella, candida, streptococcus, staphylococcus and E. coli.

PRP (Proline-rich Polypeptide):
Shown to help regulate the thymus gland (bodiescentral command for the immune system). PRP can stimulate a weakened immune system, as well as balance an overactive immune system, as in the case of many autoimmune diseases.

Lactoferrin:
An iron-binding protein with antiviral, antibacterial, anti-inflammatory properties. Lactoferrin has been implicated in the treatment of such diseases as cancer, HIV, herpes, chronic fatigue, candida albicans and other infections.

Glycoproteins: (protease and trypsin inhibitors)
Protect the immune and growth factors in colostrum from destruction by the digestive juices in the stomach and intestinal tract.

Lactalbumins:
Research indicates tremendous possibilities that Lactalbumins can be highly effective against numerous forms of cancer and viruses. Lactalbumin has also been shown in vulnerable subjects to raise brain serotonin activity, reduce cortisol concentration, and improve mood under stress.

Cytokines:
Interleukin 1 & 6, Interferon Y & Lymphokines:
Chemicals that are involved in cell-to-cell communication, antiviral and anti-tumor activity and regulation and intensity of immune responses. Cytokines help increase T-cell activity and stimulate production of immunoglobulins. One cytokine, interleukin-10, is a potent anti-inflammatory agent that has been shown to have a profound effect on pain relief. Interleukins have shown particular promise in fighting cancer.

Lysozymes:
Helps protect the body from bacterial infections. Lysozyme has actually been shown to destroy bacteria on contact. May be an effective topical antibiotic.

Growth Factors:
Medical studies have shown that the vital growth factors from bovine colostrum are practically identical to human colostrum in composition. Furthermore, it has been shown that growth factors stimulate normal growth, as well as help regenerate and accelerate the repair of aged or injured muscle, skin collagen, bone, cartilage and nerve tissues. Growth factors also stimulate the body to burn fat for fuel instead of the body's own muscle tissue in times of fasting (diet) and build lean muscle. In addition, growth factors can be used as an effective topical application for burns, injuries and skin rejuvenation.

Epithelial Growth Factor (EGF):
EGF is instrumental in protecting and maintaining the skin. Along with the other growth factors in colostrum, EGF can stimulate normal skin growth and repair cellular tissue.

Insulin-like Growth Factor I and II: (IGF-I & IGF-II)
IGF I & II are the most abundant growth factors in colostrum. They affect how the body uses fat, protein and sugar. IGF-I is one of the only substances known to stimulate the repair and growth of DNA and RNA, making it one of the most powerful anti-aging substances. IGF-I has been clinically proven to help increase lean muscle mass and may help regulate blood sugar and cholesterol levels.

Transforming Growth Factors A & B: (TGF A & B)
TGF stimulates the proliferation of cells in connective tissue and assists in the formation of bone and cartilage. It is also showing promise as a therapeutic agent in bone and wound healing. TGF can help repair tissue and may support the development of growth of the lining of the gut.

Platelet-Derived Growth Factor: (PDGF)
PDGF has been shown to help with cell division in connective tissue, smooth muscle, and fibroblasts. It may also assist in neuron survival and regeneration.

Vitamins & Minerals
The vitamins and minerals in colostrum are naturally occurring and naturally balanced.

Athletic Performance

Buckley JD, et al. Effect of An Oral Bovine Colostrum Supplement Intact on Running Performance.

Burke E. (1996) Colostrum as an athletic enhancer and help for AIDS. Nutrition Science News.

Mero A, et al. (1997) Effects of bovine colostrum supplementation on serum IGF-1, IgG, hormone, and saliva IgA during training. Journal of Applied Physiology. 83: 1144-1151.
PubMed Reference
UI: 97479511

Sparling PB, Nieman DC, O'Connor PJ. (1993) Selected scientific aspects of marathon racing : an update on fluid replacement, immune function, psychological factors and the gender difference. Sports Medicine. 15: 116-132.
PubMed Reference
UI: 93189945

Berk LS, Nieman DC, Youngberg WS, et al. (1989) The effect of long endurance running on natural killer cells in marathoners. Medicine and Science in Sports and Exercise. 22: 207-212.
PubMed Reference
UI: 90286868

Antonio, J., Sanders, M. and Van Gammeren, D. The Effects of Bovine Colostrum Supplementation on Body Composition and Exercise Performance in Active Men and Women. Nutrition 17:243-247, 2001.
PubMed Reference

General Information

Bitzan MM, Gold BD, Philpott DJ, et al. (1998) Inhibition of Helicobacter pylori and Helicobactor mustelae binding to lipid receptors by bovine colostrum. The Journal of Infectious Diseases. 177: 955-961.
PubMed Reference
UI: 98194591

Cavalli-Sforza LT, Strata A. (1987) Double-blind study on the tolerance of four types of milk in lactose malabsorbers. Human Nutrition: Clinical Nutrition 40C: 19-30.
PubMed Reference
UI: 87194017

Joseph M. and Flesch A. (1998) Research shows colostrum to be one of nature's most potent, broad-spectrum substances. Chiropractic Journal.

Cenacchi T, Baggio C, and Palin E. (1987) Human tolerability of oral phosphatidylserine assessed through laboratory examinations. Clinical Trials Journal. 24.

Ghidini A, Hicks C, Lapinski RH, Lockwood CJ. (1997) Morbidity in the preterm infant with mature lung indicies. American Journal of Perinatology. 14: 75-78.
PubMed Reference
UI: 97406454

Jochims K, Kaup FJ, Drommer W. (1994) Immunoelectron microscopical demonstration of the absorption of colostral IgG by small intestinal enterocytes in newborn rats. Research in Veterinary Science. 57: 146-151.
PubMed Reference
UI: 95116714

Efigenia M, Povoa B, Moraes-Santos T. (1997) Effect of heat treatment on the nutritional quality of milk proteins. International Dairy Journal. 7:609-612.

Klagsbrun, M. (1978) Human milk stimulates DNA synthesis and cellular proliferation in cultured fibroblasts. Proceedings of the National Academy of Sciences, USA. 75: 5057-5061.
PubMed Reference
UI: 79116260

Kume S, Tanabe S. (1993) Effect of parity on colostral mineral concentrations of holstein cows and value of colostrum as a mineral source for newborn calves. Journal of Dairy Science. 76:1654-1660.
PubMed Reference
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Le Dividich J, Herpin P, Paul E, Strullu F. (1997) Effect of fat content of colostrum on voluntary colostrum intake and fat utilization in newborn pigs. Journal of Animal Science. 75:707-713.
PubMed Reference
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Li-Chan E, Kummer A, Losso J, Kitts D, Nakai S. (1995) Stability of bovine immunoglobulins to thermal treatment and processing. Food Research International. 28: 9-16.

Nitsch A, and Nitsch F. (1998) The clinical use of bovine colostrum. Journal of Orthomolecular Medicine. 13.

Wit JN. (1998) Nutritional and functional characteristics of whey proteins in food products. Journal of Dairy Science. 81:597-608.
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Walker WA. (1999) What is the role of nucleotides and polyamines in breast milk? Acta Paediatrica. 88:1313-1315.
PubMed Reference
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McConnell MA, Brooks HJL, Borissenko MB, Buchan GA. A comparative study of immunoglobulin levels and anti-inflammatory activity in four milk products. Journal of Dairy Science, Publication forthcoming.

Warny M, Fatima A, Bostwick E, et al. (1998) Bovine immunoglobulin concentrate-Clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut. 44(2):212-7.
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Wieczorek Z, Zimecki M, Janusz M, Staroscik K, Lisowski J. (1979) Proline-rich polypeptide from ovine colostrum: its effect on skin permeability and on the immune system. Immunology. 36:879-881.
PubMed Reference
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Yamamoto A, Wada O, Suzuki H. (1987) Purification and properties of biologically active chromium complex from bovine colostrum. American Institute of Nutrition. 118(1):39-45.
PubMed Reference
UI: 88089963

Zhang T, Iguchi K, Mochizzuki T, Hoshino M, Yanaihara C, Yanaihara N. (1990) Gonadotropin-releasing hormone-associated peptide immunoreactivity in bovine colostrum. Society for Experimental Biology and Medicine. 194(3):270-3.
PubMed Reference
UI: 90287898

Growth Factors

Antonio J. (1998) Can bovine colostrum enhance levels of IGF-1? Muscle and Fitness.

Ballard F, Wallace J, Francis G, Read L, Tomas F. (1996) Des (1-3) IGF-I: a truncated form of insulin-like growth factor-I. International Journal of Cellular Biology. 28:1085-1087.
PubMed Reference
UI: 97083788

Bricker D. (1991) Colostrum: Implications for accelerated recovery in damaged muscle and cartilage, prevention of some pathogenic disease. The American Chiropractor.

Burrin D, Davis T, Ebner S, Schoknecht P, Fiorotto M, Reeds P. (1997) Colostrum enhances the nutritional stimulation of vital organ protein synthesis in neonatal pigs. American Society for Nutritional Sciences. 127(7):1284-9.
PubMed Reference
UI: 97347442

Bhora F, Dunkin, B, Batzri S, et al. (1995) Effect of growth factors on cell proliferation and epithelialization in human skin. Journal of Surgery Res. 59:236-244.
PubMed Reference
UI: 95364356

Burrin DG, Shulman RJ, Reeds PJ, Davis TA, Gravitt KR. (1992) Porcine colostrum and milk stimulate visceral organ and skeletal muscle protein synthesis in neonatal piglets. Journal of Nutrition. 122:1205-1213.
PubMed Reference
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Cass TL. Insuin-like growth factor-1 (IGF-1, Somatomedin C) blood levels are not associated with prostate specific antigen (PSA) levels or prostate cancer: A study of 749 patients. Medical College of Wisconsin, Milwaukee, WI www.worldhealth.net/news/prost-igf1/:1999.

Demarco C. (1998) Anti-aging breakthrough: Homeopathic growth factors. Let's Live.

Francis G, Upton F, Ballard J, McNeil K, Wallace J. (1988) Insulin-like growth factors 1 and 2 in bovine colostrum. Journal of Biochemistry. 251:95-103.
PubMed Reference
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Fryburg D. (1995) Insulin and insulin-like growth factor 1 enhance human skeletal muschle protein anabolism during Hyperaminoacidemia by different mechanisms. Journal of Clinical Investigations 96:1722-1729.
PubMed Reference
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Francis G, Read L, Ballard J, et al. (1986) Purification and partial sequence analysis of insulin-like growth factor-1 from bovine colostrum. Journal of Biochemistry 233:207-213.
PubMed Reference
UI: 86158708

Ginjala V, Pakkanen R. (1998) Determination of transforming growth factor-B1 (TGF-B1) and insulin-like growth factor 1 (IGF-1) in bovine colostrum samples. Journal of Immunoassay 19:195-207.
PubMed Reference
UI: 98347053

Hadsell KL, Baumrucker CR, Kensinger RS. (1993) Effects of elevated blood insulin-like growth factor-I (IGF-I) concentration upon IGF-I in bovine mammary secretions during the colostrum phase. Journal of Endocrinology. 137:223-230.
PubMed Reference
UI: 93316008

Juskevich J. (1990) Bovine Growth Hormone: Human Food Safety Evaluation. Science. 249:875-883.

Kirkpatrick CH.(1993) Structural nature and functions of transfer factors. Annals New York Academy of Sciences. 685:362-8.
PubMed Reference
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Marcotty C, Frankenne F, Van Beeumen J, Maghuin-Rogister G, Hennen G. (1991) Insulin-like growth I (IGF-I) from cow colostrum: Purification and characterization. Growth Regulation. 1(2):56-61.
PubMed Reference
UI: 93091807

Marquardt H, Lioubin MN, Ikeda T. (1987) Complete amino acid sequence of human transforming growth factor type beta 2. Journal of Biological Chemistry. 262:12127-12131.
PubMed Reference
UI: 87308213

Miers W, Barrett E. (1998) The role of insulin and other hormones in the regulation of amino acid and protein metabolism in humans. Journal of Basic and Clinical Physiology and Pharmacology. 9(2-4):235-53.
PubMed Reference
UI: 99229307

Noda K, Umeda M, Ono T. (1984) Transforming growth factor activity in human colostrum. Gann. 75:109-112.
PubMed Reference
UI: 84237261

Nowak J, Olszewski J, Kozal E. (1994) Insulin and sugar concentration changes in mammary secretion in sheep during the periparturient period. Reprod. Nutritional Development. 34:3-8.
PubMed Reference
UI: 94176019

Nowak J. (1990) Insulin and glucose concentration changes in newborn piglets after suckling the colostrum from insulin administered sows. Acta Physiol. 41(7):155-62.
PubMed Reference
UI: 92351771

Nord J, Ma P, DiJohn D, Tzipori S, Tacket CO. (1990) Treatment with bovine hyperimmune colostrum cryptosporidial diarrhea in AIDS patients. AIDS. 4:581-584.
PubMed Reference
UI: 90351575

Oda S, Satoh H, Sugawara T, et al. (1989) Insulin-like growth factor-I, GH, insulin and glucagon concentrations in bovine colostrum and in plasma of dairy cows and neonatal calves around parturition. Comp. Biochemical Physiology. 94A:805-808.
PubMed Reference
UI: 90151056

Pakkanen R, Aalto J. (1997) Review paper: Growth factors and antimicrobial factors of bovine colostrum. International Dairy Journal. 7:285-297.

Pakkanen R. (1998) Determination of transforming growth factor-B2 (TGF-B2) in bovine colostrum samples. Journal of Immunoassay. 19:23-37.

PubMed Reference

Rosenthal S, Brown E, Brunetti A, Goldfine I. (1991) Fibroblast growth factor inhibits insulin-like growth factor-II (IGF-II) gene expression and increases IGF-I receptor abundance in BC3H-1 muscle cells. Molecular Endocinology. 5:678-684.
PubMed Reference
UI: 91304432

Russell J, Feldman E. (1999) Insulin-like growth factor-I prevents apoptosis in sympathetic neurons exposed to high glucose. Horm Metab Res. 31:90-96.
PubMed Reference
UI: 99243374

Sara VR, Hall K. (1990) Insulin-like growth factors and their binding proteins. Physiological Reviews. 70:591-606.

Shimizu M, Webster C, Morgan DO, Blau HM, Roth RA. (1986) Insulin and insulin-like growth factor receptors and responses in cultured human muscle cells. American Journal of Physiology. 251:E611-5.

Shing Y, Klagsbrun M. (1987)Purification and characterization of a bovine colostrum-derived growth factor. Molecular Endocrinology. 1:335-338.
PubMed Reference
UI: 90331924

Skottner A, Arrhenius-Nyberg V, Kanje M, Fryklund L. (1990) Anabolic and tissue repair functions of recombinant insulin-like growth factor I. Acta Pediatric Scand. 367:63-66.
PubMed Reference
UI: 91022017

Sporn M, Roberts A, Shull J, Smith J, Ward J. (1983) Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science. 219(4590): 1329-31.
PubMed Reference
UI: 83146345

Tokuyama H, Tokuyama Y, Migita S. (1990) Isolation of two new proteins from bovine colostrum which stimulates epidermal growth factor-dependent colony formation of NRK-49F cells. Growth Factors. 3(2):105-14.
PubMed Reference
UI: 91000711

Tokuyama Y. (1993) Purification and identification of TGF-B2-related growth factor from bovine colostrum. Journal of Dairy Research. 60:99-109.
PubMed Reference
UI: 93171372

Tollefsen S, Lajara R, McCusker R, Clemmons D, Rotwein P. (1989) Insulin-like growth factors (IGF) in muscle development. Journal of Biological Chemistry. 264(23):13810-7.
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UI: 89340472

Tomas F, Knowles S, Owens P, et al. (1991 ) Increased weight gain, nitrogen retention and muscle protein synthesis following treatment of diabetic rats with insulin-like growth factor (IGF)-I and des(1-3)IGF-I. Biochem J. 276 ( Pt 2):547-54.
PubMed Reference
UI: 91264814

Tokuyama, H. and Tokuyama, Y. (1989) Bovine colostric transforming growth factor-B like peptide that induces growth inhibition and changes in morphology of human osteogenic sarcoma cells (MG-63). Cell Biology International Reports 13:251-258.
PubMed Reference
UI: 89208792

Ullman M, Ullman A, Sommerland H, Skottner A, Oldfors A. (1990) Effects of growth hormone on muscle regeneration and IGF-I concentration in old rats. Acta Physiological Scand 140:521-525.

Shomali M, Wolfsthal S. (1997) The use of anti-aging hormones. Maryland Medical Journal 46:181-186.
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Watson DL, Francis GL, Ballard FJ. (1992) Factors in ruminant colostrum that influence cell growth and murine IgE antibody responses. Journal of Dairy Research 59:369-380.
PubMed Reference
UI: 93017233

Immune Factors

Bocci V, Von Bremen K, Corradeschi F, Luzzi E, Paulesu L. (1991) What is the role of cytokines in human colostrum? Journal of Biological Regulators and Homeostatic Agents. 3:121-124.
PubMed Reference
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Boesman-Finkelstein M. and Finkelstein R. (1989) Passive oral immunisation of children. Lancet. 2(8675):1336.
PubMed Reference
UI: 90081062

Bogstedt AK, Johansen K, Hatta H, et al. (1996) Passive immunity against diarrhoea. Acta Paediatr. 85:125-128.
PubMed Reference
UI: 96233729

Casswall T, Sarker S, Albert M, et al. (1998) Treatment of Helicobacter pylori infection in infants in rural Bangladesh with oral immunoglobulins from hyperimmune bovine colostrum. Ailment Pharmacol Therapies 12:563-568.
PubMed Reference
UI: 98341957

Davidson G, Whyte P, Daniels E, et al. (1989) Passive immunisation of children with bovine colostrum containing antibodies to human rotavirus. Lancet. 2(8665):709-12.
PubMed Reference
UI: 89383719

Dichtelmuller W, Lissner R. (1990) Antibodies from colostrum in oral immunotherapy. Journal of Clinical Biochemistry 28:19-23.
PubMed Reference
UI: 90188232

Ebina T, Umezu K, Ohyama S, et al. (1983) Prevention of rotavirus infection by cow colostrum containing antibody against human rotavirus. Lancet. 2(8357):1029-30.
PubMed Reference

Feldmann M, Brennan F, Maini R. Role of cytokines in rheumatoid arthritis. Annual Review of Immunology 14:397-440, 1996.
PubMed Reference

Hanson LA, Ahlstedt S, Andersson B, et al. (1983) Mucosal Immunity. Annals New York Academy of Sciences 83:1-20.

Boesman-Finkelsein M, Walton NE, Finkelstein RA. (1989) Bovine lactogenic immunity against cholera toxin-related enterotoxins and Vibrio cholerae outer membranes. Infection and Immunity 57:1227-1234.
PubMed Reference
UI: 89173323

Hilpert H, Brussow H, Mietens C, Sidoti J, Lerner L, Werchau H. (1987) Use of bovine milk concentrate containing antibody to rotavirus to treat rotavirus gastroenteritis in infants. Journal of Infectious Diseases 156:158-166.
PubMed Reference
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Hirmo S, et al. (1998) Characterization of Helicobacter pylori interactions with sialylglycoconjugates using a resonant mirror biosensor. Analytical Biochemistry 257:63-6.
PubMed Reference
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Hoffman M. (1992) Transferred immune cells may help fight viral infection. Immunology. 257(5067):166.
PubMed Reference
UI: 92335854

Honorio-Franca A, Carvalho M, Isaac L, Trabulsi L, Carneiro-Sampaio M. (1997) Colostral mononuclear phagocytes are able to kill enteropathogenic Escherichia coli opsonized with colostral IgA. Scandavian Journal of Immunology. 46:59-66.
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Huppertz H, Rutkowski S, Busch D, Eisebit R, Lissner R, Karch H. (1999) Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, shiga toxin producing E. coli, and E-coli expressing intimin and hemolysin. Journal of Pediatric Gastroenterology and Nutrition. 29:452-456.
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Janusz M, Lisowski J. (1993) Proline-rich polypeptide (PRP)-an immunomodulatory peptide from ovine colostrum. Archivum Immunologiae et Therapiae Experimentalis. 41:275-279.

Jochims K, Kaup F, Drommer W, Pickel M. (1994) An immunoelectron microscopic investigation of colostral IgG absorption across the intestine of newborn calves. Research in Veterinary Science. 57:75-80.
PubMed Reference
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Kelly CP, et al. (1996) Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotixicity of C. difficile toxins. Antimicrobial Agents and Chemotherapy 40:373-379.
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Kelly G. (1999) Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alternative Medicine Review. 4(2):96-103.
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Khazenson L, Gennad'eva T, Roshchin V, Krasheniuk A, Semenova N. (1980) Activity of bovine colostral IgG in the human digestive tract. ZH Mikrobiol Epidemiol Immunobiol 9:101-106.
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Kohl S, Malloy, M, Pickering L, Morriss F, Adcock E, Walters D. (1978) Human colostral cytotoxicity: I. Antibody-dependent cellular cytotoxicity against herpes simplex viral-infected cells mediated by colostral cells. Journal of Clinical Laboratory Immunology. 1:221-224.
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Korhonen H, Suvaoja EL, Ahola-Luttilia H, et al. (1995) Bactericidal effect of bovine normal and immune serum, colostrum and milk against Helicobactor pylori. Journal of Applied Bacteriology 78:655-662.
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Lawton JW, Shortridge KF, Wong RL, Ng MH. (1979) Interferon synthesis by human colostral leucocytes. Archives of Disease in Childhood 54:127-130.
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LeFranc-Millot C, Vercaigne-Marko D, Wal J.-M, et al. (1996) Comparison of the IgE titers to bovine colostral G immunoglobulins and the F(ab')2 fragments in sera of patients allergic to milk. Int Arch Allergy Immunol. 110:156-162.
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Leszek J, Inglot AD, Janusz M, Lisowski J, Krukowska K, Georgiades JA. (1999) Colostrinin: a Proline-Rich Polypeptide (PRP) Complex Isolated from Ovine Colostrum for Treatment of Alzheimer's Disease. A Double - Blind Placebo-Controlled Study. Archivum Immunologiae et Therapiae Experimentalis. 47(6):377-85.
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Lissner R, Thurmann P, Merz G, Karch, H. (1998) H. Antibody reactivity and fecal recovery of bovine immunoglobulins following oral administration of a colostrum concentrate from cows to healthy volunteers. International Journal of Clinical Pharmacology and Therapeutics 36:239-245.
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Loimaranta V, Carlen A, Olsson J, Tenovuo J, Syvaoja E.-L, Korhonen H. (1998) Concentrated bovine colostral whey proteins from Streptococcus mutans/Strep. sobrinus immunized cows inhibit the adherence of Strep. mutans and promote the aggregation of mutans streptococci. Journal of Dairy Research 65:599-607.
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McClead RE, Butler T, Rabbani GH. (1988) Orally Administered Bovine Colostral Anti-Cholera Toxin Antibodies: Results of Two Clinical Trials. The American Journal of Medicine 85:811-816.
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Michalek SM, McGhee JR. (1977) Effective immunity to dental caries: passive transfer to rats to antibodies to Streptococcus mutans elicits protection. Infection and Immunity 17:644-650.
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Michalek SM, McGhee JR, Babb JL. (1978) Effective immunity to dental caries: dose-dependent studies of secretory immunity by oral administration of Streptococcus mutans to rats. Infection and Immunity. 19:217-224.
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Mitra AK, Mahalanabis D, Ashraf H, Unicomb L, Eeckels R, Tzipori S. (1995) Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: a double-blind, controlled clinical trial. Acta Paediatr. 84:996-1001.
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Moro I, Abo T, Crago SS, Komiyama K, Mestecky J. (1985) Natural Killer Cells in Human Colostrum. Cellular Immunology. 93:467-474.
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Naber P, et al. (1996) Inhibition of adhesion of Clostridium difficile to caco-2 cells. Immunology and Medical Microbiology. 14:205-209.
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Ouwehand A, Salminen S, Skurnik M, Conway P. (1997) Inhibition of pathogen adhesion by B-lactoglobulin. International Dairy Journal. 7:685-692.

Ogra P, Losonsky G, Fishaut M. (1983) Colostrum-derived immunity and maternal-neonatal interaction. New York Academy of Science 409:82-95.
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Ogra SS, Ogra PL. (1978) Immunologic aspects of human colostrum and milk. The Journal of Pediatrics. 92:546-549.
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Palmer EL, Gary Jr. GW, Black R, Martin ML. (1980) Antiviral activity of colostrum and serum immunoglobulins a and g. Journal of Medical Virology. 5:123-129.
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Parodi PW. (1996) Milk fat components: possible chemopreventive agents for cancer and other diseases. The Australian Journal of Dairy Technology. 51:24-32.

Petschow B, Talbott R. (1994) Reduction in virus-neutralizing activity of a bovine colostrum immunoglobulin concentrate by gastic acid and digestive enzymes. Journal of Pediatric Gastroenterology and Nutrition . 19:228-235.
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Plettenberg A, Stoehr.A, Stellbrink.J, Albrecht.H, Meigel W. (1993) A preparation from bovine colostrum in the treatment of HIV-posotive patients with chronic diarrhea. Clinical Investigator 71:42-45.
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Pincus C, Nussenweig V. (1971) Regulation of the Immune Response: Suppressive and enhancing effects of passively administered antibody. Journal of Experimental Medicine. 133:987-1003.
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Pironi L, Miglioli M, Ruggeri E, et al. (1990 ) Relationship between intestinal permeability to EDTA and Inflammatory activity in asymptomatic patients with Crohn's disease. Digestive Diseases and Sciences. 35(5):582-8.
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Quigley JD, Martin KR, Dowlen HH, Wallis LB, Lamar K. (1994) Immunoglobulin concentration, specific gravity, and nitrogen fractions of colostrum from Jersey cattle. Journal of Dairy Science. 77:264-269.
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Rautiainen E. (1998) The prevalence of Mycoplasma hyopneumoniae in pig herds in western Finland based on the demonstration of antibodies in colostrum by ELISA. Acta Vet Scand. 39:325-330.
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Ritchie D, Becker E. (1994) Update on the management of intestinal cryptosporidiosis in AIDS. The Annals of Pharmacotherapy. 28:767-778.
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Robert Service. (1994) Triggering the First Line of Defense. Research News. 265.
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Rump JA, Arndt R, Arnold A, et al. (1992)Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum. Clinical Investigator. 70:588-594.
PubMed Reference
UI: 93005401

Saif L, Smith K. (1985) Enteric viral infections of calves and passive immunity. Journal of Dairy Science. 68:206-228.
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UI: 85158472

Sandholm M, Honkanen-Buzalski T. (1979) Colostral trypsin-inhibitor capacity in different animal species. Acta Vett.Scand. 20:469-476.
PubMed Reference
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Lactoferrin

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Rebornne First Colostrum

Your First Food!

In the first 72 hours after giving birth, a mother produces a very special, pre-milk breast fluid called colostrum. It contains numerous substances which protect the infant from infections and other diseases, and stimulates growth and over fifty different health-supportive processes. some of which last a life time. These powerful factors have been shown to be beneficial also to people of all ages.

What About Bovine Colostrum

All mammals produce colostrum ,however, cow (bovine) colostrum is the only animal form that can be utilized by humans. Since dairy cows produce more colostrum than is needed by the newborn calves, the excess can be processed for human use as a powder for children and adults. Bovine colostrum contains even more health supportive substances than human colostrum.

One of the most important ingredients in colostrum is the immune globulin, IgF-1 which stimulates healing, muscle growth, and the production of immune cells, reduces the need for insulin, and increases the burning of fat. Bovine colostrum contains ten times the amount of IgF-1 than human colostrum.

What About Colostrum for Children

Many babies today are not breast fed even in the first critical few days. They have no source of colostrum unless they are given a supplement, since no milk or baby formula contains this important substance. Infants, with a developing immune system, are vulnerable to bacteria and virus infections.

They also need stimulation to many basic metabolic processes necessary during their rapid growth and their entry into the world outside the protective immunity of the mothers womb. Colostrum capsules may be easily opened and the powder sprinkled into baby formula and later into the child's food.

What About Colostrum for Adults

As we age we produce less immune and growth factors that are needed to heal tissue damage and to fight disease. Colostrum can provide many of these important factors which are often included in anti-aging programs.

What About Energy and the Physical Body

In addition to IgF-1 and TgF-A & B, Epithelial Growth Factor (EgF) regenerate muscle, nerve, bone and cartilage - affecting all of the structural cells of the body, and helping to increase the anabolic process of protein syntheses, build lean muscle tissue, and burn fat for energy.

Constituents of Rebornne First Colostrum

1. Immunoglobulins (antibodies): contains all of the immunoglobulins -IgA, IgD, IgE, IgG, IgM.
2. Lactoferrin: an iron-binding protein which releases iron to the red blood cells.
3. Proline-Rich-Polypeptide (PRP): regulates under activity or over activity of the immune system.
4. IgF-1: Insulin Like and Transforming Growth Factors-stimulates T-cell production, muscle growth, and reduces insulin need.
5. Leukocytes: stimulate production of interferon.
6. Hydrogen peroxide producing enzymes: attack bacteria.
7. Lysozyme: destroys bacteria and viruses.
8. Cytokines: stimulate and regulate immune response, communications, and tumor destruction.
9. Interlukin 10: reduces inflammation.
10. Long chain sugars: block bacteria from attaching to mucus membranes.
11. Orotic acid: supports red blood cell integrity.

Excellent source of sulfur micro-nutrients, including MSM, or Methyl Sulfonyl Methane. In fact, colostrum is one of the richest known sources of MSM. It also contains other powerful components including two of the most potent anti-inflammatory compounds known. This makes it far more powerful than the new sulfur-based remedies, as Glucosamine Sulfate, alone.

Preparation of Rebornne First Colostrum ?

Pure bovine origin colostrum is harvested from controlled, healthy cows at a state licensed, New Zealand MAF AND USDA inspected, dairy. It is shown by laboratory testing to be free of bacteria, herbicides, pesticides, and antibiotics. It is collected in the 72 hours after the birth of the cows second calving at which time the highest concentration of immune and growth factors are present. It is then frozen and sent to a licensed food processing facility for processing as a powder, which is finally measured into Vegicaps? in an FDA and GMP registered manufacturing laboratory.

Unlike many complex proteins, colostrum is not reduced to individual amino acids in the stomach because of natural digestive enzyme inhibitors. This permits colostrum to pass intact into the intestinal tract for absorption into the blood stream.

Colostrum's Growth Factors

1. Regenerate and accelerate normal growth of aged or injured muscle, bone, cartilage, skin collagen and nerve tissue.
2. Help burn fat for fuel instead of muscle tissue in times of fasting or diet.
3. Help build and retain lean muscle.
4. Repair our body's vital DNA and RNA.
5. Balance and regulate blood sugar levels.
6. Heal burns, surgeries, cuts, abrasions, and mouth sores with topical application.
7. Helps control infection and pain associated with gingivitis, sensitive teeth and dental work.
8. Help regulate blood glucose levels and "brain chemicals"(increasing Seretonin production), providing alertness, better concentration and "feeling good".

Colostrum's Immune Factors

1.IgA and IgG help to neutralize toxins and other unwanted invaders in the Lymphatic and circulatory systems.

2.IgD and IgE are highly antiviral.

3.IgM is a powerful bacteria fighter.

4.PRP (Polyproline-Rich-Peptides) help boost an underactive immune system and help restore the thymus gland, which produces the vital T-cells that fight viruses and antigens, to optimal functioning capability. PRP helps balance an overactive immune system as is present in autoimmune disease-conditions in which the body actually attacks itself. This may make colostrum helpful for illnesses such as:

• Chronic Fatigue Syndrome
• Fibromyalgia
• Multiple Sclerosis
• Rheumatoid Arthritis
• Lupus, and
• Scleraderma.

5.Lactoferrin in numerous research studies has been shown to be a potent, broad-spectrum natural antibiotic and anti-viral agent. Lactoferrin is also a potent anti-oxidant which inhibits the harmful effects of free radicals.

6.Osteoclasts are cells which degrade bone, undermining its structure, creating the porosity and loss of bone strength called osteoporosis.Osteoblasts, on the other hand, are bone-building cells. As we age, the number of osteoblasts decreases and osteoclasts increase in number. This is especially true of post-menopausal women, as a decline in estrogen levels has been shown to lead to an increase in osteoclasts.

7.A study reported in the Journal of Natural Medicine shows that TgT-B which is found in nature only in colostrum, is naturally produced by the osteoblasts, the bone-building cells. The study also proved that TgF-B dramatically increased cell apoptosis (cell death) among the osteoclasts, the bone destroying cells.

8.The study suggests that TgF-B could help slow or even prevent the development of osteoporosis.

Colostrum is the only readily available natural source of growth factors, including TgF-B. We therefore recommend that anyone who desires to positively affect bone density and strength, take colostrum on a regular basis. We also recommend that post-menopausal women see their health practitioner for tests of hormone levels. The research findings suggest that the combination of careful hormone replacement therapy with a daily intake of colostrum could be extremely effective against this common scourge among so many members of our society.

To take advantage of the growth factors, take your Colostrum in capsule form on an empty stomach, 20 minutes before eating or taking other supplements, followed by a large glass of water which will help to "wash" the capsules through to the small intestine where they are best absorbed.

Be aware that heat destroys Colostrum's effectiveness. Processing is critical and tablet formulations and formulations of colostrum intermixed with other herbs and nutrients can virtually destroy all of its effectiveness.